There are come into being a series of deep seated fault zone and a great deal CO2 degasification point through the collision between Indian and Asian plates. Meanwhile the degasification point will release various gases including to N2, CO2, H2S, CH4, He, and so on. He gases is an inertia chemical element that cannot react chemical action but physical process. So Helium and its isotope is a sensitive geochemistry tracer reagent that can distinguish the mantle-derived gases. There are different mother earth constitution will formative uneven distributing Helium isotopes. The mother earth constitution of the Central and the Northern of Tibet attribute Bangong Co-Nujiang suture zone. It takes place obvious mantle degasification that shows the suture zone' depth reaches the upper mantle and it's a lithosphere deep seated fault zone. The mantle-derived Helium of all samples averagely occupies the whole Helium about 1.4%~1.7% which reflects the bottom of the fault zone is lower opening degree and tight close. As a result it lies on the intensity extrusion constitution environment and incrassated crust. The terrestrial heat current release large number of the mantle-derived helium from the southwest of Yunnan province. It show the section exist mantle-derived magma intrude activity on shallow crust. Nujiang suture zone takes place obvious mantle degasification that shows the suture zone' depth reaches the upper mantle and it's a lithosphere deep seated fault zone. The mantle-derived Helium of all samples averagely occupies the whole Helium about 26.2%, the tiptop about 48.8% which reflect the fault zone is repressing extent structure environment. Meanwhile the area is the strongest mantle-derived helium assoil. On the other way round the Central of Yunnan province (Xiaojiang fault) entirety is differ from the southwest of Yunnan province. The mantle-derived Helium of all samples averagely occupies the whole Helium about only 2.27%, the maximum about 8.9%. We can suppose that the Xiaojiang fault zone is the furthest east edge of the collision between Indian and Asian plates. It is a crust fault but is the boundary of the Yangzi ancient land plate to the collision zone. So the helium isotope shows mantle-derived on the west to this crust fault and less mantle-derived helium on the east. The Xianshuihe fault zone on the west of Sichuan province is an especial mother earth constitution place that is know as "the Bermuda Triangle of Geology". The mantle-derived Helium of all samples averagely occupies the whole Helium about only 8.1%. The mean value larger than the subarea of Tibet' value and!the subarea of Yunnan' value except the southwest of Yunnan. So the great strike-slip fault-the Xianshuihe fault zone run through the whole lithosphere in part and have a tend to incision the upper mantle.