The Huangshan granites are characterized by high SiO2 ( >75 %), low calcium CaO (0.51 ~ 0.86 %), poor MgO, relatively high alkali and high FeO*/MgO ratio (8.28 ~ 87.20). Geochemical analysis shows that the granites is extremyly depleted in Ba, Sr, and Eu (δEu = 0.01 ~ 0.13), rich in strong incompatible elements such as Rb, Th and U. The contents of high field strong elements such as Zr, Nb, Y and Ga are relatively high. Major and trace elements signature indicates that the Huangshan granites belong to Atype. The tetrad effect is presence in the granites' REE distribution diagrams. Some trace elements behavior can't be controlled by charge and radius of ions, such as, extremely low ratios of K/Rb and Zr/Hf and distinctly high K/Ba. The features can be observed only in highly evolved magma which strongly interactes with hydrothermal fluid. Compared with the calcalkaline Taiping granitoids, the highly evolved Huangshan Atype granites have relatively low initial 87Sr/86Sr ratios (0.707，but 0.710 for the Taiping granitoids) and high εNd(t) values (-4.45 ~ -4.87，but -6.21~-6.40 for the Taiping granitoids). The twostage model ages (TDM2) for the Huangshan granites is 1.24 ~ 1.33Ga, clearly smaller than the model ages of the Taiping granitoids (1.44 ~ 1.45Ga), implying that a great deal of asthenospheric mantle material entered into the parent magma of the Huangshan granites. It is concluded that the change from the calcalkaline Taiping granitoids to the alkaline Huangshan granites refers the Mesozoic lithospheric thinning of the southeastern Yangtze craton.