Based on OSL dating, this paper reports the paleoenvironmental and climatic evolution in Rutog area, Tibet, since 6510 a BP. Ostracods and pollen record indicated a warm and wet period (6170~5540 a BP) in middle Holocene in Rutog area. Climate varied frequently after this period and tended to be cold and dry, which was similar to modern climate. After disassembly of the 43~30 ka BP paleolake between Lumajiangdong Co and Bangong Co, the topographic low Rutog area became an enclosed lake basin, and connected to the adjacent Bangong Co for some time. After a short time of enlargement during warmwet period in Holocene, the lake shrinked and eventually dried up during 1570~1380 a BP, similar to the modern environment. The Megathermal in Holocene became shorter and climate changed more frequently during this period in the deep part of QinghaiTibetan Plateau.