The East China had experienced frequent crustal movement, complex tectonic evolution, intense magnetism and diverse mineralization since the Mesozoic ear. It is an important area where the different tectonic regimes transform. The middle and lower Reaches of the Yangtze River is a typical area where the tectonic system converts from Mesozoic Tethys tectonic regime to the Pacific tectonic regime. It is a focal point of the two tectonic regimes meets and transform, with the relationship between spatial and temporal evolution with lithospheric material reorganization and structural reconstruction. The structural knot of middle and lower reaches of Yangtze River is the result of tectonic regime transition between Tethys and Pacific tectonic regimes. The Dabie Orogenic belt, Tan-Lu Fault and Middle-lower Yangtze metallogenic belts directly record the process of the two tectonic regimes transition, spatial-temporal relations between deposition-tectonic-magmatic-metallogenic and dynamic setting. The middle and lower reaches of Yangtze River structural knot has distinct regularity of structural overlapping. The magmatic activity and the distribution of the metallogenic belt of the Middle and Lower Reaches of the Yangtze River area are controlled strongly by NE-SW trending structural belt represented by Yangtze River compound structural belt and NW-SE trending structural zones represented by Tongling-Hangzhou structural belt. The structural knot of middle and lower reaches of Yangtze River has the mineralization law of node-type. The crossing positions between different scales NE-SW trending structural belt and NW-SE trending structural belt are the locations of ore concentration areas and important deposits.