The Chashan Sb-W deposit is located in Dachang Sn-polymetallic ore field, Nandan, Guangxi. Fluorite is one of major gangue minerals in this deposit, which is closely related with antimony and tungsten mineralization. Geochemical study on trace elements (including rare earth elements, REE) of fluorite was carried out systematically in this paper. The results show that the total REE concentrations of fluorite range from 4.03×10-6 to 77.53×10-6, with an average of 38.72×10-6. The chondrite-normalized REE distribution pattern is flat, with slight fractionation between LREE and HREE, and slightly Ce negative anomaly (δCe = 0.76~0.87) and relatively strong Eu positive anomaly (δEu = 1.48~2.94). These features are clearly different from the characteristics of REE (LREE-rich pattern, with obvious negative Eu anomaly) for different types of ores, host rocks and magmatic rocks from Dachang Sn-polymetallic ore field. Furthermore, compared with other elemental abundance of the continental crust and Devonian strata in the western Guangxi, the fluorite from Chashan deposit is riched in Sb and W, and depleted in Cu, Zn, Co, Ni, etc. By comprehensive analysis and comparison the ore-forming fluid closed associated with Sb-W mineralization of Chashan deposit would not be sourced from the Devonian host rocks, may be derived dominantly from deep-circled fluids.