Weibei uplift in Ordos Basin have unique tectonic position and complex evolution history. In this area, the organic matter abundance of carbonate rocks in Ordovician of Lower Paleozoic is high and it is the most favorable area for natural gas exploration. However, due to the lack of effective thermal indicators in carbonate rocks of Ordovician, it is difficult to determine the thermal evolution degree and reconstruction thermal history. Based on the large number of measured bitumen reflectance data in carbonate rocks of Ordovician and combined with other thermal indicators data such as vitrinite reflectance, apatite and zircon fission track in the overlying Paleozoic and Mesozoic strata, this paper reconstruct tectonic-thermal history of Weibei uplift. The simulation results show that the thermal evolution degree of Paleozoic Ordovician is high in the north and west area and low in south and east. The equivalent vitrinite reflectance of Ordovician is generally greater than 2.00% in the stage of over-mature dry gas. The apatite fission track data indicate that the uplift-cooling time of Weibei Uplift has characteristic of early in southern and late in the northern. The uplift-cooling time of Ordovician- lower Permian in southern area is early, about 102-107Ma.in northern uplift since 65Ma, the main period of uplift since 40Ma. the uplift-cooling time since 65Ma in northern was late, main uplift- cooling time is since 40Ma.Uplift- cooling time of Weibei uplift began at the late Early Cretaceous（102-107Ma）,rapid overall uplift happened since 40Ma.The thermal evolution history study results show that the Ordovician strata experienced maximum Paleotemperature in the Early Cretaceous which occurred a tectonic-thermal event, paleogeothermal gradient reached 4.60℃ / 100 m. The early Cretaceous was the main gas generation period of Ordovician source rocks, main gas generation period is controlled mainly by tectonic-thermal event of early Cretaceous. The research on thermal evolution degree and history of Ordovician in Weibei uplift have an important significance to the study of gas accumulation conditions and natural gas exploration.