The Nanling region is an important concentration area of nonferrous metal resources. Polymetallic metallogenesis in the Mesozoic is closely associated with widespread granitoid. In this paper, we have summarized the temporal and spatial characteristics of tungsten-tin-molybdenum-bismuth and copper (-molybdenum)-lead-zinc-gold-silver deposits. Based on research of rock masses’ features, we discuss and contrast the petrological and mineralogical characteristics of the two types of metallogenic granitoid, and point out that: (1) tungsten-tin-molybdenum-bismuth deposits-forming granitoid is dominated by biotite granite derived from crustal materials, while some displays information of mantle. Rock-forming minerals include quartz, potassium feldspar, plagioclase, biotite, and muscovite. Poikilitic texture of quartz, feldspar and biotite is common. Most plagioclases are albites, with mean An value of 8. Bioties, whose MF value ranges from 0.001 to 0.5311, are haughtonite, siderophyllite and aluminium siderophyllite. Amphiboles are occasional and their value of Mg# ranges from 0.21 to 0.53. (2) granitoid related to copper (-molybdenum)-lead-zinc-gold-silver deposits is dominated by granodiorite. Rock-forming minerals include quartz, plagioclase, potassium feldspar, biotite and amphibole, while poikilitic texture is rarely observed. Most plagioclases are oligoclases. Biotites are eastonites, with MF value ranging from 0.5120 to 0.7216. Amphiboles are gedrites and bidalotites, with Mg# value ranging from 0.48 to 1.00. The petrological and mineralogical differences between the two types of metallogenic granitoid could be indicators for prospecting in Nanling granitic area.