The Wulonggou gold ore-field is an important gold ore concentrate area in the middle part of eastern Kunlun orogenic belt. Gold deposits in the area are controlled by three gold-bearing structural fracture zones (Yanjingou, zone, Yinshigou-Hongqigou zone and Sandaoliang-Kushuiquan zone). In this study we investigated the characteristics of the mineralization and alteration in different part of these three zones, and achieved that there are two kinds of alteration in the ore-field. One is early alteration related to gold deposit, which is controlled by linear fault structure zone. The other is later alteration related to polymetallic ore deposit，which is controlled by multi-trend fracture and disseminated sulfide–rich granitic complex. The gold deposit formed early are partly destroy by the alteration and polymetallic mineralization related disseminated sulfide–rich granitic complex highly emplacement later. The further prospecting for gold deposit is in the area where developed more linear fault fracture zone and less multi-trend fracture and disseminated sulfide–rich granitic complex.