Lying in the northwestern sector of Karakorum orogenic belt,Qieliekeqi iron deposit is located in the famous Taxkorgan iron metallogenic belt of Western Kunlun area of Xinjiang. In recent years, the geological prospecting in the Qieliekeqi iron deposit makes a great progress. Qiebei iron deposit has been discovered in the north mining area and the whole deposit scale has been upgraded to a largescale iron ore. For these reasons, based on the metallogenic geological characteristics summary, petrology, mineralogy, geochemistry and stable isotope geochemistry, this article is in the study of the genesis of ore deposit. This work is essential and important for the similar research of ore genesis in the same region. The new Qieliekeqi iron deposit include four orebodies group(Number: I, II, III, IV) and northern blind orebodies group (Number: Fe1～5). 26 orebodies are determined in these orebodies group. The main embedded stratums are biotite quartz schist, muscovite schist and marble of MiddleUpper Silurian Dabangou Group. The orebodies are broadly distributed in simple stratoid or lenticular, with stable occurrence, shallow depth and huge reserves. Siderite rocks have a massive, layered, banded structure which was mainly resulted from the original sedimentation, and a miarolitic, vein, disseminated structure which represents the late metamorphism and hydrothermal superimposition. The automorphichypidiomorphic granular textures are the main ore textures. The mineral composition is simple, only with original metallic minerals siderite (content 70%～80%) and ore oxide, gangue minerals quartz (10%～25%), muscovite (3%～5%) and a few pyrites, graphites, tourmalines and apatites. The formation of this oredeposit might be divided into three stages: initial sedimentary stage, regional metamorphic stage and hydrothermal transformation stage. Through to the forming environment research, it showed the study area in Silurian was a sedimentary environment of shallow sea facies. Not only AlFeMn diagram of ore samples indicated that the iron deposit formed from the hotwater sedimentation, but also the geochemical characteristics with light REE losses, positive Eu anomaly ( δEu 1.54～2.82) and no exception of Ce (δCe 0.90～0.90) all clearly reflect the same conclusion. In addition, the stable isotope (δ18O, δD) analysis of siderite samples showed the oreforming fluid was superimposed genesis. All things considered, genesis of the Qieliekeqi iron deposit belongs to marine facies hotwater sedimentary type, and late hydrothermal superimposed transformation.