Asone key national strategic resource, sandstonetype uranium deposits are one of the most important types in the modern world. This paper decribes in great detail the distribution and ratios of sandstonetype uranium ore deposits at home and abroad, discussed interlayer permeability sandstone type and submerged permeability sandstone typeuranium deposits formed by supergene fluids. The results show that distinct redox zoning of interlayer permeability sandstone typeuranium deposit occurs in terms of surface color, mineral combination and geochemistry, and moreover, bacteria zoning phenomenon. Color zoning show remarkable different characteristics among oxidized zones, redox transitional zones and reduced zones; mineral combination differs among the different zones; geochemical zoning is also defined by U, TOC contents and Fe2+/Fe3+ and Th/U ratios. In addition, the quantities of bacteria, such as sulfate reducing bacteria (SRB), thiobacilli, ferrobacteria, and nitrobacteria, vary considerably among the different zones, and there is conspicuous positive correlation between the magnitude of SRB and TOC. By analysis of carbon and sulfur isotope in the mineralization belt, we find that SRB has involved in the metallogenic process and infer that SRB may be the dominant factor causing carbon and sulfur isotopic fractionation. As a whole, color, mineral, geochemical, and bacteria zonings all have coupling relationship with the redox zoning. This study proposes the mechanism of sandstonetype uranium deposits involved by bacteria and geochemical reactions, and a number of key scientific problems needed to be solved urgently through summarizing metallogenic model of interlayer permeability sandstone type and submerged permeability sandstone typeuranium deposits. The exceptional responses of typical sandstone typeuranium deposits to geophysical, geochemical, prospecting exploration and remote sensing have great guiding significance to searching for sandstone typeuranium deposits.