Uplift-erosion of Ningwu basin and its peripheral plutons has important significance for the Mesozoic-Cenozoic tectonic evolution of the Shanxi block. The fission track analysis made from Ningwu basin and peripheral plutons shows that apatite fission track ages vary from 97 Ma to 47 Ma, and zircon fission track ages vary from 161 Ma to 141 Ma. The fission track recorded four uplift erosion events: the early stage of Early Cretaceous (145~125 Ma), the late stage of Late Cretaceous (85~70 Ma), the early stage of Eocene (59~53 Ma) and the late stage of Late Oligocene (28 Ma). The fission track data show that multiple uplift erosion events have occurred since Late Paleozoic. Meso-Cenozoic tectonic evolution of Shanxi block has temporal and spatial differences. The fission track age of peripheral plutons samples is older than sedimentary strata samples, indicating that peripheral plutons was uplifted erosion prior to the basin and the uplift erosion of northeast Shanxi block was earlier than that of southwest. The formation of fracture was earlier in the southwest of Shanxi rift system. The development of rift system extends from south to north, which is consistent with strata conservation record. In the Mesozoic, the regional tectonics formed a series of en-echelon complex anticlines and synclines. In the Cenozoic, Indian Ocean plate compression on Eurasia may have formed the current geomorphological pattern of Shanxi block. It is closely related to the multi-stage tectonic movement in the northeastern margin of Tibetan Plateau.