The geothermal resources in the eastern Himalayan syntaxis are abundant and have bright prospects for exploitation and utilization, which is of great significance to the high- quality development of Tibet and the realization of the double- carbon goals. Based on the field investigation, hydrochemical isotope analysis, geothermal temperature scale and silicon- enthalpy model calculation, the hydrogeochemistry and storage characteristics of thermal groundwater are analyzed, and the exploitation and utilization potential of geothermal resources are evaluated in this study. The results show that the distribution of geothermal resources in eastern Himalayan syntaxis are controlled by active faults, and thermal groundwater mainly occurs in the Yarlung- Zangbo suture zone, the Tongmai- Tongdeng fault zone and the Jiali- Chayu active fault zone. Most of the thermal groundwater in the study area has the characteristics of high temperature and high content of TDS, metasilicic acid and metaboric acid, which meets the certification standards for physiotherapy mineral water. The thermal groundwater in study area originates from the atmospheric precipitation, and the recharge elevation is 4309 m to 4988 m. The circulation depth of thermal groundwater is between 1403 m and 7202 m, and the temperature of geothermal reservoir is about 65. 5℃ to 303. 2℃. Affected by thermal convection, the thermal groundwater flows upward along the weak parts of the structure, and receives 72% to 96% of cold- water mixing, forming different types of geothermal displays on the surface. The total amount of geothermal energy resource in the study area is 173. 42×1018 J, and the recoverable geothermal energy resource is 26. 013×1018 J. The total amount of thermal groundwater resource is about 2. 191×1010 m3 and the recoverable resource is 3. 286×109 m3. The current coefficient of resource exploitation is 0. 86% to 27. 84%, showing great exploitation potential. The cascade and integrated utilization measures and technologies of geothermal resources in study area are the key research directions in the future.