The Middle- Late Cambrian (509~485 Ma) was an unsteady period in Earth history, during which several carbon isotope shifts and biological extinction events occurred, indicating that the Earths environment may have experienced drastic changes. In this study, we report systematic δ13C, 87Sr/86Sr and Ce anomaly data of carbonate from the Wangcun section in South China. Our results suggest that four transient shallow marine oxidation pulses (CeN/CeN*<0.8) occurred in South China during the Middle- Late Cambrian, which located in Wuliuan (ca.509~504.5 Ma), Early Drumian (~505 Ma), Guzhangian (ca.500.5~497 Ma) and Early Paibi (ca.497~496 Ma), respectively. The oxidation pulses that occurred in Early Paibi and Wuliuan may be indicative of widespread oxidation of global surface seawater, while the other two pulses may represent local oxidation confined to the marginal seas in South China. When compared with the latest biostratigraphic findings, we suggest that the timing of the onset of the shallow marine oxidation pulses largely corresponds to the peak of trilobites and overall species diversity in South China, which indicates that shallow ocean oxygen rises may have contributed to the development of biodiversity animal radiations. The relative trends in seawater δ13C and 87Sr/86Sr values indicate that enhanced continental weathering may have resulted in increases of nutritional matter input to the sea and thus increase of marine primary productivity, which may have been an important driver of the shallow marine oxidation pulses.