The Grand Bend of the Yarlung Zangbo River region, located in the southeastern region of the Tibetan Plateau, is one of the fastest- uplifting and geomorphic evolution regions on earth. The combined forces of internal and external dynamics result in frequent landslides, posing significant challenges to the planning and construction of infrastructure projects such as highways, railways, and hydropower facilities. This article aims to delve into the impact of landslides on the evolution of landforms by examining the interconnectedness between topography, river erosion, tectonic activity, and landslide distribution. Our study reveals that landslides play an important role in the evolution of landforms in the area. We find that the local topographic relief and slope gradient exhibit a nonlinear positive correlation with the occurrence of landslides. As a response to regional crustal uplift and rapid river incision, the landforms in this region adapt by increasing slope steepness and the rate of landslide occurrence. Through a hypsometric integral analysis of different geomorphic evolution stages, we observe that as surface erosion intensity increases, the ratio of landslide area, as well as the average and median values of landslide slope gradient, also increase. This indicates the significant contribution of landslide erosion to rapid erosion processes. Furthermore, we note that river incision exerts noticeable control over landslides. Specifically, the Jiala- Jinzhuzangbo section of the Yarlung Zangbo River, characterized by steep longitudinal slopes and high river power, exhibits a high density of landslides. Additionally, we find a positive correlation between the development of landslides and fault density, while the distance to faults shows a negative correlation. Seismic landslides induced by intense fault activity also make a significant contribution to geomorphic erosion in the region. The findings of this study enhance our understanding of landslide development and provide significant insights for engineering planning and construction, as well as disaster prevention and mitigation efforts in the Grand Bend of the Yarlung Zangbo River region.