The coastal area of Guangdong Province exhibits a significant abundance of hot spring resources, making it an important geothermal resource region characterized by medium- low temperature hydrothermal activity. Through field investigation, the crust- mantle temperature structure of the hot spring geothermal system in this area was determined using magnetic, gravity, and seismic methods. The results indicate a Curie temperature of 550℃ and a Moho surface temperature ranging from 635℃ to 812℃. The mantle exhibits weak upwelling, and the thermal background displays a slight elevation. Interestingly, two distinct dVs negative regions were identified at a depth of 20 km beneath the hot spring geothermal anomaly areas located in both western and eastern Guangdong province. These anomalies are hypothesized to represent high- temperature hydrothermal activity zones in the lower crust. Genetic analysis of the hot spring geothermal system shows that the NE deep- large fault is an important thermal conduction structure. This fault not only acts as a preferential channel for the upward transfer of heat from deep sources but also facilitates heat exchange between groundwater and the surrounding rock. The heat source for this geothermal system comprises three distinct components: a deep mantle heat source, a lower crustal heat source originating from the high- temperature hydrothermal active areas, and a near- surface strata heat source with a high heat generation rate. The primary water source is atmospheric precipitation, which infiltrates underground through fault fractures and weathered granite, subsequently being heated by the heat sources. This heated groundwater accumulates near the surface of thermal conduction structure, forming a subsurface heat reservoir. Finally, it emerges as hot springs in structurally favorable locations. The average depth of hot water circulation within the hot spring geothermal system in eastern Guangdong is greater than that observed in western Guangdong.