The three major metallogenic belts (Middle- Lower Yangtze River Valley Cu- Fe belt,Jiaodong Au belt, and Liaodong polymetallic belt) flanking the eastern side of the Tanlu fault zone exhibit near- equidistant parallel distribution and represent crucial metal enrichment zones in eastern China. Based on multi- scale geophysical datasets including gravity, magnetic, deep seismic reflection, and magnetotelluric surveys, this study systematically examines their geophysical characteristics spanning from mantle lithosphere through crust to near- surface domains. Our analysis integrating mantle channel flow theory reveals that: ① Metallogenic materials originated from deep mantle lithosphere; ② The Tanlu fault zone serves as the principal pathway for ascending mantle- derived materials, coordinating with secondary faults (Yangtze fault, Jiaobei fault, and Liaodong fault) to jointly control metallogenesis. Comparative evaluation of geophysical methods demonstrates complementary strengths in tracking mantle- derived magmas through crustal levels. Integrated application of gravity- magnetic- electromagnetic- seismic methods effectively traces mantle material migration pathways, while 3D geophysical imaging enables full- process monitoring from mantle sources to near- surface reservoirs, significantly enhancing identification capabilities for critical metallogenic system elements (source- transport- reservoir) across multiple scales. This integrated approach provides theoretical support for deep mineral exploration targeting.