The study of the Paleo- Tethys tectonic evolution and its mineralization are relatively weak. In this paper on the basis of defining the specific evolutionary stage and relative decelopmental spatial range of the Paleo- Tethys, from the perspective of regionanal mineralization, based on the late Paleozoic- early Mesozoic mineralization facts in the northern part and adjacent areas of the Qinghai- Tibet Plateau, it is proposed that the south and north branches of the Paleo- Tethys ocean, and the north branch between the Kangxiwa- Animqing- Mianlue suture belt and the Xijinwulan- Jinshajiang- Ganzi- Litang suture belt are the main ocean of the Paleo- Tethys. It substrate to the north low angle ocean- continent subduction of the Andean- like active continental margin, in the Animqing suture belt and Kunlun and west Qinling orogenic belt, forming a large number of endogenous metal deposits; to the south high angle ocean- ocean subduction, forming the Mariana- like trench- rac- basin system and the south branch of the Paleo- Tethys represented by the Longmuco- Shuanghu- suture belt between the south and north Qiangtang, which is the result of post arc expansion. According to the evolution model of the Paleo- Tethys tection cycle, the Paleo- Tethys mineralization is devided into two types: the major extensional and the major compressional tectional seyyings. The former is characterized by the output of early Devonian Xiarihamu super- large magmatic nickel- cobalt sulfide deposit, Devonian Xichenchangba super- large Sedex lead zinc deposit, late carboniferous Maorkansu largr sedimentary manganese deposit and early Permian Derni Cyprus VMS type copper- cobalt; the latter with numerous medium- small late Permian- Triassic porphyry- skarn type polymetallicdeposits, epithermal gold antimony deposits, VMS type polymetallic deposits, terrestrial volcanic rock type lead- zinc deposits output, especially Triassic magmatic hydrothermal gold deposits in the east Kunlun and west Qinling, and late Triassic Jiajika and Dahongliutan super- large pegmatite lithium- beryllium deposits exposed in the east and west ends of Bayanhar terrane. Large- scale mineralization event is the result of tectonic transformation, and the cracking event of the Paleo- Tethys tectonic cycle opening formed the Xiarihamu super large magmatic nickel- cobalt sulfide deposit; the closure of the Paleo- Tethys ocean and Indosinian orogeny of the continent- continent collision and post- collision created the development of the most important pegmatite lithium and other rare metal metallogemic belt in West Kunlun- Songpan Ganzi, China. It is urgent to strengthen the overall systematic research of tectonic evolution- magmatic activity- metallogenic response of the Paleo- Tethys, and serve the new round of prospecting breakthrough strategi action in the northern part of Qinghai- Tibet Plateau.