In recent years, deep fissure pore brines have been found in Paleogene-Neogene anticlinal tectonic strata in the central and western Qaidam Basin, Qinghai Province. These brines have large reservoir thickness, high content of potassium, lithium and boron resource elements, and some metallogenic conditions have reached the boundary or industrial mining grade, which have great potential for further prospecting. In this study, the sedimentary and salt-forming evolution of Paleogene-Neogene strata, reservoir characteristics and element geochemistry of brine deposits in Qaidam Basin are reviewed in detail, and the spatio-temporal metallogenic characteristics and genetic mechanism of brine resource elements are summarized. The results show that the reservoirs of brines in the west of the basin are gray mudstone and mudstone, while in the central of the basin are mudstone and siltstone. The content of potassium, lithium and boron resources gradually decreases from the west (Shizigou -Nanyishan) to the central (Hongsanhan - Yanhu) and to the north (Eboliang - Lenghu - Nanbaxian), which is closely related to the migration and evolution of the sedimentary center of the ancient lake basin. The metallogenic model of the Paleogene-Neogene anticlinal fissure pore brine deposit is established, which has a good guiding significance for future exploration evaluation and metallogenic prediction.