In the Palaeogene, the strata, sedimentary and structural evolution in North Shandong can be comparable with those in Southwest Shandong. The study on strata and sedimentary characteristics of palaeogene in the rock outcrops area of Southwest play a great referable role to the recovery of palaeo-environment and the study on sedimentary characteristics of palaeogene in the rock-covered area of North Shandong. The strata and sedimentary characteristics of the two areas are compared in this paper. According to the sedimentary distribution of the Guanzhuang Group in Southwest Shandong, the regularity is found out that basins are formed from south to north and east to west from Late Cretaceous to Early Eocene in the Southwest Shandong. According to the comparison of characteristics of sediment and faults between Southwest Shandong and Jiyang Depression, another regularity is found out that Tancheng-Lujiang fracture underwent sinistral share, the faults of NW-striking are derived in Southwest Shandong and Jiyang Depression from the Late Jurassic to the Early Eocene; the structural transition age is in the late Early Eocene, during which the EW-striking faults are formed in Southwest Shandong and Jiyang Depression; the most active age of dextral share of Tancheng-Lujiang fracture is in the Middle and Late Eocene, during which the NE-striking faults are formed in Southwest Shandong and Jiyang Depression.