Based on the Middle-Late Paleozoic pillow lava and Permian-Triassic tectonic melange, this paper shows that there is a melange zone along Qinzhou-Cenxi-Luoding-Yunfu. According to an analysis of the tectonic melange and regional tectonic framework, it is emphasized that a branch of the western Guangdong and eastern Guangxi. The tectonic evolution of the Tethys in Guangdong, Guangxi and adjacent regions is also disscussed.