The changes of conjugate angles between NE- and NW-trending faults and their functional relationship with the amount of crustal shortening are used to calculate the amount of the late Himalayan crustal deformation in the central section of the Qinghai-Tibet Plateau. The results indicate that a huge amount of crustal shortening took place in a nearly N-S direction in the central part of Qinghai-Tibet Plateau in the late Himalayan age, with the average shortening amount reaching 30% , while a huge amount of crustal extension took place in a nearly E-W direction there, with an average extension amount reaching about 74%. The crustal strain in the middle sector of the Qinghai-Tibet Plateau in the late Himalayan age was also manifested by obvious regionalization and a tendency of progressively decreasing changes from north to south.