The study on interstratified oxidized zone is usually focused on the behaviors of uranium and related elements, such as Se, Mo, V, Re and Ga, while the major elements including Si, Al, Na, K is not sufficient. In fact, the physical and chemical conditions such as Eh, pH, temperature and pressure will be changed obviously with the migration of ore-bearing fluid and reactions between water and rocks during the interlayer oxidation. And, therefore, the behavior of major element such as Si, Al, Fe, Na and K will response to such change. The first varies appears in the form of the minerals which contains such elements, and result in the content of above element. These major elements can be divided into 3 parts as activity, sub-activity and non-activity based on the density of migration in and out.