It is necessary to carry out a re-exploration in the maturely explored metallogenic district, but predictive mineral discoveries in these districts have been obstructed by some special difficulties such as ineffective model and large depth of the undiscovered ore deposits. For enhancing predictive discovery of hidden ore deposits, the strategies we should adopt include innovation of exploration model, application of advanced exploration techniques and integration of multiple sets of information. The innovation of the exploration model must incorporate the new metallogenic concepts that are based on the geodynamic anatomization. The numerical geodynamic modeling is an effective way to innovate the model. Advanced techniques should be used for enhancing detecting depth and accuracy. It must be based on detailed and correct geological data. The information synthesis is to integrate multiple sets of data for giving a more credible and visual prospectivity map by using of the GIS and data- and knowledge-driven integration methods, which can extract useful information from every set of data as much as possible. Guided by these strategies, we implemented a prediction exploration program in the Fenghuangshan ore field of the Tongling Cu district, which results in a successful discovery of a hidden ore deposit.