The distinct species of bacterial are first found in ore hosting bed rock of large Shihongtan interlayer oxidized zone type sandstonge uranium deposit in Turpan--Hami Basin, northwest China, by means of sampling, bacterial culured and distinguished. The aerobic bacterium including iron bacterium, thiobacillus, nitrobacteraceae, distribute in oxidizing zone, the anaerobic bacterium do in ore hosting bed rock. There are well zonation of biologic geochemistry in species and quantity. This zonation is in concordance with zonation of geochemistry. Based on metabolic chacteristic and experimental result of sulfates reducted by sulfate reducing bacteria, the paper analyes role of bacterial in oxidized zone formed, uranium oxidized and solubilizated, uranium reducted and metallogenesis.