The paper analyzes the impacts of intensive tectonic compression on natural gas migration and accumulation in the later Himalayan period, taking the Kela 2 gas field in the Kuqa foreland basin as an example. Tectonic compression makes the fluid pressure rapidly increase and changes the previous relatively stable fluid potential field. The fault zone is a lower stress zone and becomes a lower potential area because of not producing the fluid pressurization or producing the fluid pressurization less than that of the surrounding rock, becomes the collecting zone of natural gas migration, which makes potential of the fault zone higher. Tectonic compression lets to the strata producing fractures and faults opening, makes the vertical gas potential gratient be greatly bigger at the same time and enhances the vertical migration force of natural gas from the lower source rock along the opening faults. The accumulation gas near the fault zones rapidly migrates towards upper strata along the opening faults and charges laterally the sand bodys located under the regional cap rock, accumulates in the lower gas potential area. The faulted anticline and the anticline located under the gypsum—salt strata in Kuqa foreland thrust belt is the lower gas potential area in the later Himalayan period, is also the place that has the opening oil source fault and where the vertical gas potential gratient has be greatly bigger and has good preservation conditions, becomes the favorable gas accumulation area. The strong tectonic compression in the foreland basin of the central and western China has significant impact on the natural gas accumulation. So the study for impact of tectonic compression on natural gas accumulation has important theory and application for guiding oil and gas exploration in foreland basin.