There are abundant of deep seated xenoliths included in the Cenozonic basalt at Fangshan, Changle, Shandong Province. They are dominated by spinel lherzolite and pyroxenite with rare harzburgite, clinopyroxenite and wehrlite. According to the petrography, mineral chemistry and equilibration temperatures and pressures estimates of harzburgite , lherzolite and pyroxenite xenoliths, all of these three type xenoliths are derivered from lithospheric mantle, reaching the depth ~41 ~ 66.7 km. Clinopyroxenite and wehrlite xenoliths develop at depths much shallower, and have close genetic relationship with those three mantle xenoliths. “Melt—rock” interaction widely exists in almost all xeoliths, as well as in the xenocrysts of the Cenozonic basalts. Various reaction rims and new formed crystals have been found in the interaction belt between basalt/basaltic melts and different minerals in pyroxenite, wehrlite and lherzolite in addition to harzburgite xenoliths: The chemical reaction formula (Mg, Fe)2SiO4 (forsterite）+ melts (primary magma) = (Mg, Fe)2SiO4（chrysolite）+melts (evolved magma) can be used to explain the course of the olivine rim poor in Mg and enriched in Fe; The pink reaction margin interacted between clinopyroxene and basaltic magma, with high content of Ti, Al and Fe, low content of Si, Mg, whose Mg# are lower than phenocryst in basalt; As the formula orthopyroxene + melts=olivine + SiO2 (melts) + clinopyroxene exists in the complicated three reaction belts, the chemical component of new generated mineral particles (olivine and clinopyroxene) have a tendency towards the component of basaltic magma; The reaction rims of spinel interacted with basaltic magma are also rich sources of Fe and Ti, lack of Mg and Al, much high Cr#, have a tendency towards forming ilmenite. Both of the “melt pocket” exist in lherzolite and pink reaction rims appear in sieve texture clinopyroxene of wehrlite suggest that the two types of xenoliths have experienced at least two periods of the “melt—rock” reaction. Along with the evolution of the lithospheric mantle, refractory harzburgite can be modified into relatively fertile lherzolite due to the melts refertilization, and basaltic melts would interact with lherzolite afterwards, generated into further enriched wehrlite, while Fangshan harzburgite have endured low grade “melt—rock” interaction, don’t possess the distinguishing characteristics of thick, cold and refractory Archean lithospheric mantle. The reaction between deep seated xenoliths and melts is extensively happened, which is one significant replacement mode of North China Craton, leading to the disappearing of Ancient lithospheric mantle. The component of melts is mainly basaltic.