The tectonic uplift and growth process of the Tibetan Plateau and its resource and environmental effects are an important proposition in the scientific research of the earth system.Especially the link between the Tibetan Plateau uplift and the inner Asia aridification during the Cenozoic still stays a dispute question.In this paper,we will try to discuss and discriminate which part of the Tibetan Plateau has the most significant effect on the inner Asia aridification.Methods:Based on the present geographical and landscape change evidence from Naqu to Golmud along 109 national highway,the results of large scale machine observations and simulations and present geological phenomenon in the east Kunlun Mountains to discuss the effects on the inner Asia aridification.Results:The east Kunlun Mountains have a significant blocking effect on the Indian monsoon going inland furtherly and it is an important moisture barrier.Conclusions:Combining the highly time consistent of the east Kunlun Mountains’ tectonic uplift and the inland aridification as well as the present geographical and landscape change evidence from Naqu to Golmud,all indicate that tectonic uplift of the east Kunlun Mountains have an important impact on the inner Asia aridification or at least the Qaidam Basin aridification since the late Oligocene. However,the northern hemisphere glaciation since ~3.6 Ma contributes much more to the aridification of the inner basins than the tectonic activities of the east Kunlun Mountains.