Geothermal energy is a safe, clean and stable source of renewable energy. The Yangjiang area of Guangdong Province has great potential for the exploitation of geothermal resources , but the related study is not sufficient.. Thermal infrared remote sensing technology can effectively delineate geothermal anomaly areas and predict buried faults. In this paper, based on Landsat 8 remote sensing data, we analyzed the relationship between ground temperature, geothermal anomalies and human activities. Meanwhile, atmospheric correction method was used to predict potential geothermal anomalies in the study area. As a result, 9 high- temperature geothermal anomaly areas are obtained without the influence of anthropogenic heat, and 4 low- temperature geothermal anomaly areas are obtained without the influence of lake water and altitude. On this basis, the temperature and vegetation drought index of the study area was calculated by using land surface temperature normalized vegetation index, and 23 potential buried faults were predicted. Finally, combined with lithology and fault structure, five geothermal target areas were effectively delineated, which were mainly distributed in the southwest of the study area and near Xinzhou Town. The research results are helpful for predicting geothermal anomaly areas of development prospects, identifying and delineating target areas and predicting concealed faults in Yangjiang area, which is very significance for the further study of geothermal resources in this area.