The Early Cambrian witnessed an explosive mineralization event of barite, forming a series of large to super- large deposits in southeastern Guizhou, China, for example, the Dahebian barite deposit. These deposits, together with the Cambrian barite metallogenic belt at Gongxi, Hunan Province, collectively constituting a crucial component of the Jiangnan barite metallogenic belt which is the most concentrated barite resource region in China, with cumulative barite reserves of approximately 240 million tonnes, demonstrating global representativeness. This paper collected and repeatedly sorted out a large amount of geological data, according to which the geological characteristics, spatiotemporal distribution, metallogenic geological conditions and ore- controlling factors were comprehensively analyzed, the metallogenic regularity were summarized, and prospecting direction were proposed.Methods:Based on recent exploration progress and metallogenic studies, this paper systematically summarized the distribution characteristics and the metallogenic regularity of the Cambrian barite deposits in southeastern Guizhou province. It also further identifies regional exploration directions.Result:The Cambrian barite deposits in southeastern Guizhou exhibit widespread distribution, high resource concentration, and clustered occurrences. The three most prolific barite enrichment zones are: 1) Dahebian—Gongxi (the primary enrichment zone), 2) Meilang—Yajin, and 3) Laowenxi—Bingxi. Systematic comparisons have revealed distinct differences among these zones in deposit scale, sedimentary sequences, ore textures/structures, and elemental/isotopic compositions, likely attributable to differential material supply paleo- seawater chemistry, and microbial activities in ore- controlling rift basins. Notably, an negative correlation exists between the thickness of barite orebody and underlying chert: Specifically, economic barite mineralization developes well where the thickness of the chert are 0~10 m, but becomes thin or pinch- out where the chert exceed 20 m.Conclusion: Recent exploration breakthroughs at the concealed footwall of the Pingdi Fault (F1), where industrial- grade orebodies were first intersected, combined with the progress of peripheral survey, propose a prioritized exploration strategy: 1) priority targeting of the F1 footwall for large to super- large barite deposits, 2) systematic expansion of prospecting in known enrichment zones, and 3) innovative exploration leveraging spatial relationships between deposits. The F1 footwall exhibits exceptional potential, with high prospects for yielding breakthroughs in identifying large to super- large barite deposits.