After the collision between the Indian Subcontinent and the Asian Continent, the Indian Subcontinent is subducting below the Asian Continent. The continental collision and land- to- land subduction not only caused the crust of the Qinghai—Xizang(Tibet) Plateau being shortened and thickened, but also led to significant changes in the geomorphological environment and deep structures of the vast area around the plateau. Is there a large amount of material wriggling from below the plateau to South China Craton and/or North China Craton? Does it cause the uplift of the Yunnan—Guizhou Plateau? In this paper, high- resolution seismic tomography is used to study the creep of materials from below the plateau and the uplift of the Yunnan—Guizhou Plateau. Seismic tomography shows that during the collision and subduction between the Indian Subcontinent and the Eurasian Continent, the lithospheric material of the Qinghai—Xizang Plateau was extruded under the upper Yangtze Craton, and the extrusion occurred in the middle of the lithospheric mantle at a depth of 73~113 km, along the route of Yidun—Xichang—Dongchuan—Anshun. One of the consequences of the extrusion of material from the central lithospheric mantle of the Qinghai—Xizang Plateau is the increase of the lithospheric volume, and causing uplift of the Yunnan—Guizhou Plateau.