Objective: Saline aquifer CO2 geological storage is an important reserve technology for achieving carbon neutral-ity. Screening suitable formation is a prerequisite for the site selection of saline aquifer CO2 geological storage projects. The northeastern part of the Ordos Basin, a high carbon emission area, was taken as an example. Methods: And the geological characteristics of 4 potential storage reservoir-cap combinations was analyzed. Based on the three criteria of storage potential, safety and economic and engineering suitability, 14 screening in-dicators were established for saline aquifer CO2 geological storage. The entropy weight method was used to ana-lyze the weights of different indicators, and the final screening is carried out based on the TOPSIS method. Results: The analysis results show that the weights of the 14 screening indicators are between 4.72% and 13.29%, among which the cap thickness has the highest weight, and the reservoir burial depth, reservoir permea-bility, caprock breakthrough pressure, and cumulative reservoir thickness have relatively high weights. The TOP-SIS method ranking score results show that the middle and upper storage reservoir-cap combinations is the most suitable CO2 saline aquifer geological storage in the northeastern part of the Ordos Basin. Conclusions: The middle and upper storage reservoir-cap combinations should be used as the planar site se-lection and subsequent saline aquifer CO2 geological storage project optimization formation.